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KMID : 1022820150060010001
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Journal of Multiple Sclerosis and Neuroimmunology
2015 Volume.6 No. 1 p.1 ~ p.8
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The Strategy of Treatment of Neuromyelitis Optica Spectrum Disorder
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Huh Jung-Won
Kim Su-Hyun
Kim Ho-Jin
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Abstract
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Neuromyelitis optica (NMO) is an autoimmune inflammatory disorder of central nerve system that is characterized by severe optic neuritis and transeverse myelitis. Since the discovery of anti-aquaporin 4 antibodies, the concept of NMO has expanded as a NMO spectrum disorder (NMOSD), which is distinct from multiple sclerosis. As NMOSD often causes severe disability, early initiation of effective therapy is very important to prevent attack-related disability. Although there are no level I or II evidence studies for NMO treatment, cumulated clinical experience for NMO treatment over the last decade brought growing body of evidence for the use of immunosuppressive agents. We review the various therapeutic options for NMOSD and propose treatment strategies based on previous reports.
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KEYWORD
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Neuromyelitis optica, Neuromyelitis optic spectrum disorder, Treatment
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